The Clark Lab

Clark Lab Publications


Semi-Reduction of Allenes to Access Deuterated Allylic Isotopomers, Isotopologs and Enantioisotopomers

Qi, L.; Thorat, R. A.; Maxwell, B. D.; Gladding, J. A.; Rivera Arzola, A. J.; Sancheti, S. P.; Sonstrom, R. E.; Tang, X.; Anderson, I. J.; Pate, B. H.*; Clark, J. R.*

Collaborative work with Vertex Pharmaceuticals, University of Virginia and BrightSpec Inc.

Angew. Chem. Int. Ed. 2026, e25850

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H2O2-Responsive Anticancer Prodrug: Synthesis, Precision Deuteration in search of In Vivo Metabolites, and Activation Pathway

Saxon, E.^; Stambekova, D^; Ponnamperumage, T. N. F.; Clark, J. R.*; Peng, X.*

^co-first authors

J. Med. Chem. 2025, 68, 25026-25037

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Regioselective Cu-Catalyzed Hydrosilylation of Internal Aryl Alkynes

Sloane, S. E.; Sancheti, S. P.; Hendy, M. S.; Smith, K. M.; Thorat, R. A.; Senkum, H.; Clark, J. R.*

Org. Lett. 2025, 27, 1412-1416

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Mechanistic and Computational Insights into Factors Impacting Asymmetric Intramolecular Fe-catalyzed Nitrene Transfer into C-H Bonds

Seo, K.; Zhang, Y.; Trinh, T. A.; Kim, J.; Qi, L.; Clark, J. R.; Liu, P.*; Schomaker, J. M.*

ACS Catal. 2025, DOI: 10.1021/acscatal.5c00222

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Precision Deuteration Using Cu-Catalyzed Transfer Hydrodeuteration to Access Small Molecules Deuterated at the Benzylic Position

Sloane, S. E.; Vang, Z. P.; Nelson, G.; Qi, L.; Sonstrom, R. E.; Alansari, I. Y.; Behlow, K. T.; Pate, B. H.*; Neufeldt, S. R.*; Clark, J. R.*

JACS Au, 2023, 3, 1583-1589

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Assignment of the Absolute Configuration of Molecules That are Chiral by Virtue of Deuterium Substitution Using Chiral Tag Molecular Rotational Resonance Spectroscopy

Vang, Z. P.; Sonstrom, R. E.; Scolati, H. N.; Clark, J. R.*; Pate, B. H.*

Chirality, 2023, 35, 856-883(Invited Submission for Special Issue)

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Rapid Enantiomeric Excess Measurements of Enantioisotopomers by Molecular Rotational Resonance Spectroscopy

Sonstrom, R. E.; Vang, Z. P.; Scolati, H. N.; Neill, J. L.; Pate, B. H.*; Clark, J. R.*

Org. Process Res. Dev. 2023, 27, 1185-1197. (Invited Submission for Special Issue: Advances and Applications in Catalysis with Earth-Abundant Metals)

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Highly Selective Catalytic Transfer Hydrodeuteration of Cyclic Alkenes

Hintzsche, S. H.; Vang, Z. P.; Rivera Torres, E.; Podoski, M.; Clark, J. R.*

J. Label. Compd. Radiopharm. 2023, 66, 86-94

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Enantioselective Synthesis of Enantioisotopomers with Quantitative Chiral Analysis by Chiral Tag Rotational Spectroscopy

Mills, M. D.; Sonstrom, R. E.; Vang, Z. P.; Neill, J. L.; Scolati, H. N.; West, C. T.; Pate, B. H.*; Clark, J. R.*

Angewandte Chemie International Edition 2022, 61, e202207275 (Received the Very Important Paper VIP designation)

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Three-Component Coupling Reactions that Generate          1,3-Dienes

Sloane, S. E.; Behlow, K. T.; Mills, M. D.; Clark, J. R.*

Science of Synthesis Knowledge Updates. 2022, 2, 389. DOI: 10.1055/sos-SD-146-00001

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Conjugated Diene Synthesis by Rearrangement of 1,3-Dienes to 1,3-Dienes

Mills, M. D.; Clark, J. R.*

Science of Synthesis Knowledge Updates. 2022, 2, 441. DOI: 10.1055/sos-SD-146-00034.

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Highly Regioselective Copper-Catalyzed Transfer Hydrodeuteration of Unactivated Terminal Alkenes

Reyes, A.; Rivera Torres, E.; Vang, Z. P.; Clark, J. R.*

Chemistry – A European Journal 2022. 28, e202104340 (Featured in Org. Chem. Highlights)

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Copper-Catalyzed Transfer Hydrodeuteration of Aryl Alkenes with Quantitative Isotopomer Purity Analysis by Molecular Rotational Resonance Spectroscopy

Vang, Z. P.; Reyes, A.; Sonstrom, R. E.; Holdren, M. S.; Sloane, S. E.; Alansari, I. Y.; Neill, J. L.; Pate, B. H.; Clark, J. R.*

Journal of the American Chemical Society 2021, 143, 7707-7718.

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Late-Stage Intermolecular Allylic C-H Amination

Ide, T.; Feng, K.; Dixon, C.F.; Teng, D.; Clark, J.R.; Han, W.; Wendell, C.I.; Koch, V.; White, M.C.*

Journal of the American Chemical Society 2021, 143, 14969- 14975.

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Catalytic Transfer Deuteration and Hydrodeuteration: Emerging Techniques to Selectively Transform Alkenes and Alkynes to Deuterated Alkanes

Vang, Z. P.; Hintzsche, S. J.; Clark, J. R.*

Chemistry – A European Journal 2021, 27, 9988-10000. (Selected by the editors as an outstanding review-type article)

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Copper-Catalyzed Formal Transfer Hydrogenation/Deuteration of Aryl Alkynes

Sloane, S. E.; Reyes, A.; Vang, Z. P.; Li, L.; Behlow, K. T.; Clark, J. R.*

Organic Letters 2020, 22, 9139-9144

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Challenges Facing Young Scientists in Academia and Industry in the United States from the Lens of a Millennial Academic

Clark, J. R.

Chemistry – A European Journal 2020, 26, 15759-15762

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Published Works Prior to Independent Career

Clark, J. R.; Feng, K.; Sookezian, A.; White, M. C. “Manganese-Catalyzed Benzylic C(sp3)-H Amination for Late-Stage Functionalization.” Nature Chemistry 2018, 10, 583-591 (Featured on the cover of Nature Chemistry. Also featured in Chemical and Engineering News May 7, 2018 p 11).

Howell, J. M.; Feng, K.; Clark, J. R.; Trzepkowski, L. J.; White, M. C. “Remote Oxidation of Aliphatic C-H Bonds in Nitrogen-Containing Molecules.” J. Am. Chem. Soc. 2015, 137, 14590-14593.

Diver, S. T.; Clark, J. R. “Ene-Yne Metathesis.” Comp. Org. Synth II. 2014, 5, 1302-1356.

Clark, J. R.; Griffith, J. R.; Diver, S. T. “Ruthenium Hydride Promoted Dienyl Isomerization: Access to Highly Substituted 1,3 Dienes.” J. Am. Chem. Soc. 2013, 135, 3327-3330.

Clark, J. R.; French, J. M.; Jecs, E.; Diver, S. T. “Geminal Alkene-Alkyne Cross Metathesis Using a Relay Strategy.” Org. Lett. 2012, 14, 4178-4181.

Clark, J. R.; French, J. M.; Diver, S. T. “Alkene Metathesis Approach to β-Unsubstituted Anti-Allylic Alcohols and Their Use in Ene-Yne Metathesis.” J. Org. Chem. 2012, 77, 1599-1604.

Clark, J. R.; Diver, S. T. “Atom Economy in the Metathesis Cross-Coupling of Alkenes and Alkynes.” Org. Lett. 2011, 13, 2896-2899.

Clark, D. A.; Clark, J. R.; Diver, S. T. “Alkenol-Alkyne Cross Metathesis.” Org. Lett. 2008, 10, 2055-2058.